Elderly with dementia-related psychosis not approved use ; increased risk of death or cerebrovascular events eg, stroke, TIA. Cardio- or cerebrovascular disease. Discontinue if neuroleptic malignant syndrome occurs or if DRESS is suspected; consider discontinuation if tardive dyskinesia occurs. Monitor for hyperglycemia, hyperlipidemia; do fasting blood glucose and lipids testing at beginning, and during therapy.
Monitor for weight gain. History of seizures. Conditions that affect metabolism or hemodynamic responses. Narrow angle glaucoma. Urinary retention.
Significant prostatic hypertrophy. History of paralytic ileus or related conditions. For bipolar disorder, it is important to remain on medicines in the long term because every time you become ill, there is more chance of you becoming ill again. Olanzapine can be used as a long-term medicine, but there are other choices and lithium is still thought to be the best long-term medicine for bipolar disorder.
You should discuss your options with your doctor. For schizoaffective disorder, it is probably best to keep taking the olanzapine for several years to reduce the chances of the illness coming back. We know less about schizoaffective disorder, but it has some similarities to bipolar disorder and some similarities to schizophrenia. Depression is usually treated with an antidepressant medicine, and olanzapine is sometimes added to an antidepressant for more severe depression.
For people with severe depression, it is best to continue the antidepressant medicine for at least two years to stop the illness from coming back. The doctor is likely to recommend continuing olanzapine for the same length of time.
You will get the best effect from olanzapine if you take it every day at the dose prescribed by your doctor. Make sure that you know your dose. If it is not written on the label, check with your pharmacist or doctor.
It is usually recommended to take olanzapine at bedtime because it can cause sleepiness as a side effect. However, it is important to choose a time of day to take it that you can easily remember, which could be bedtime, a mealtime, or when you brush your teeth.
For the plain-coated tablets, swallow them whole with a drink of water - if you chew them, they taste bitter. Put orodispersible tablets melts on your tongue and let them dissolve there. You can also dissolve these in a glass of water, orange juice, apple juice or milk and then drink it all down. A doctor or nurse can give you an injection in your bottom that provides a long-lasting dose of olanzapine, lasting for two or four weeks. You may need to take tablets alongside the injection, especially while the dose builds up.
Every time you have the injection, you will be asked to wait at the centre for at least three hours so that they can check that the injection is not giving you too much olanzapine in one go. It is slowly working in your body all the time between injections. If you forget to take it by bedtime, just start again on the next day. Do not take a double dose. If it is less than 12 hours before your next dose of olanzapine, then do not take the missed dose because taking the doses too close together could cause more side effects.
If you miss your appointment for your injection, contact your doctor or nurse straight away to make another appointment. If you forget to take your tablets for a while, or you miss an injection, you may start getting your old symptoms back. You should talk to your doctor if this happens. Once you start taking an antipsychotic, the brain adjusts to having a new level of dopamine around.
If you stop taking the antipsychotic all at once, the balance starts to change again. You could get your old symptoms back. Stopping this medicine quickly, or reducing the dose too much at once, may cause your old symptoms to come back, or cause you some withdrawal effects. You may get your old symptoms back if you stop olanzapine for a while.
You can also get withdrawal effects, including:. It is better to agree stopping with a doctor who will reduce your dose gradually. This is likely to take a few weeks. You will probably go for checks with your doctor after you stop olanzapine to check that you still feel better. If you have taken more olanzapine than the dosage recommended by the doctor who prescribed it to you, you must get medical help immediately — even if you do not feel any different.
Olanzapine can sometimes cause serious side effects. Tell your doctor immediately if you experience unusual movements mainly of the face or tongue. Go to hospital immediately if you think you may have developed a blood clot symptoms are usually swelling, pain and redness in the leg - a clot may travel through blood vessels to the lungs causing chest pain and difficulty breathing.
Also go to hospital and tell the doctor you are taking olanzapine if you develop a combination of fever, faster breathing, sweating, muscle stiffness or drowsiness. Stopping olanzapine suddenly can cause withdrawal effects and stopping it too early could cause your illness to come back. See your doctor if you want to stop taking olanzapine because it is better to come off it gradually. You might feel sleepy or dizzy in the first few days after taking olanzapine. Do not drive a car, ride a bike or operate machines until you see how this affects you.
If you are pregnant, or thinking of becoming pregnant, please read the pregnancy section under the 'Side Effects' tab because olanzapine may affect the developing baby. Take your medicine with you to show to the doctors. Tell them how much you have taken. Get a friend to go with you, if you can, just in case you feel ill on the way. Go to a doctor or hospital straight away if you get any of the following symptoms while taking olanzapine:. You need to talk to your doctor or pharmacist before starting treatment with olanzapine if any of the following apply to you:.
You should have your weight, blood sugar, blood fats, blood pressure and pulse measured regularly during early treatment, then at least every six months to a year after that, depending on your age.
You should also have your blood sugar tested when you start, after one month, and then every four to six months after that.
The doctor might also check your heart with an electrocardiogram ECG and check your blood pressure. They might also check your height and development. If you have periods, they may also check whether they are regular. Please do not be worried by the side effects listed on this page. Some people take olanzapine without any side effects or with only a few mild side effects. Some side effects wear off after a few days or weeks.
If you think you might be getting a side effect from olanzapine, then you should discuss this with your doctor, nurse, or pharmacist. Do not stop taking the tablets until you talk to your doctor, or you may get withdrawal symptoms as well. Olanzapine use has been linked to an increased risk of developing diabetes among some young people.
Symptoms include:. If you already have diabetes, you may need to increase the amount of medication you take for this alongside taking olanzapine. We use cookies We use cookies on this website to store user preferences, aid in accessibility and analyse our traffic. Read our cookie policy.
Accept all cookie usage. Update cookie preferences. Open guide menu Skip to guide menu. I am a young person I am a parent I work with young people. Open site search Open main navigation. View shareable links View Basket : 0 items. Guide Menu for Olanzapine. Hide Show guide menu. Guide contents jump to section About olanzapine Olanzapine and everyday life Uses, warnings, safety and side effects About this information More information and advice.
Olanzapine: what I wish I had known. Taking olanzapine and sertraline: Elizabeth's story. About olanzapine. Please note. Always talk to your doctor about your situation and whether this medication is for you. Thinking about trying medication? Read our guide. How olanzapine works.
Olanzapine and everyday life. These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider. Multiorgan hypersensitivity reactions drug reaction with eosinophilia and systemic symptoms [DRESS] : Potentially serious, sometimes fatal, multiorgan hypersensitivity reactions have been reported.
Tardive dyskinesia TD is a side effect that develops with prolonged use of antipsychotics. If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your healthcare provider immediately.
All patients taking either first or second generation antipsychotics should have an Abnormal Involuntary Movement Scale AIMS completed regularly by their healthcare provider to monitor for TD. Second generation antipsychotics SGAs increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. Olanzapine may lower your blood pressure. Medications used to lower blood pressure may increase this effect. This risk is increased when these medications are given as an injection.
Cigarette and other types of smoke can decrease levels of olanzapine. Let your healthcare provider know if you start or stop smoking cigarettes. Nicotine patches do not impact olanzapine levels. It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking olanzapine. It will probably take several weeks to see big enough changes in your symptoms to decide if olanzapine is the right medication for you.
Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein.
The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research.
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